Proteomics applications in next generation induced pluripotent stem cell models.
Manda, Vyshnavi , Pavelka, Jay , Lau, Edward
Publication Details
- Journal: Expert Rev Proteomics
- Volume: 21 (4 )
- Pages: 217-228
- Published: Apr 2024
- Type: Journal Article
Abstract
INTRODUCTION: Induced pluripotent stem (iPS) cell technology has
transformed biomedical research. New opportunities now exist to create new organoids, microtissues, and body-on-a-chip systems for basic biology investigations and clinical translations. AREAS COVERED: We discuss the utility of proteomics for attaining an unbiased view into protein expression changes during iPS cell differentiation, cell maturation, and tissue generation. The ability to discover cell-type specific protein markers during the differentiation and maturation of iPS-derived cells has led to new strategies to improve cell production yield and fidelity. In parallel, proteomic characterization of iPS-derived organoids is helping to realize the goal of bridging in vitro and in vivo systems. EXPERT OPINIONS: We discuss some current challenges of proteomics in iPS cell research and future directions, including the integration of proteomic and transcriptomic data for systems-level analysis.
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Added: January 15, 2026 | Updated: January 15, 2026